Drug Interactions

Allopurinol can potentially interact with a number of other medications (see Drug Interactions With Allopurinol).

What If I Take an Overdose?

It is not known what exactly to expect from an overdose. If you happen to overdose on allopurinol, seek immediate medical attention.
(Click Allopurinol Overdose for more information.)

What Should I Do If I Miss a Dose?

If you do not take your allopurinol as scheduled, take your missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose of the medication.

How Does It Work?

Allopurinol works by lowering uric acid levels. This helps to treat gout, as this condition occurs when the levels of uric acid become so high that crystals form inside the joint. The medication lowers uric acid levels by inhibiting xanthine oxidase, an enzyme responsible for producing uric acid in the body. By inhibiting xanthine oxidase, allopurinol slows down the rate at which the body produces uric acid.
Allopurinol works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, allopurinol is usually taken along with other gout medications, at least temporarily.

When and How to Take Allopurinol

Some general considerations include the following:
  • Allopurinol comes in tablet form. It is usually taken one or more times per day, depending on the dose.
  • It is usually best to take allopurinol just after a meal, as this may decrease stomach upset.
  • For the medication to work properly, it must be taken as prescribed. Allopurinol will not continue to work if you stop taking it.
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Allopurinol Medication Information

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