Drug Interactions With Allopurinol

Didanosine
Allopurinol may increase the level of didanosine in the blood, increasing your chance of side effects. In general, this combination of medications should be avoided, if possible.
 
Diuretics
Diuretics may increase the risk of toxic effects of allopurinol. If you take allopurinol with a diuretic, your healthcare provider should periodically test your kidney function (using a simple blood test). Problems due to combining a diuretic with allopurinol are more likely to occur in people with kidney problems.
 
Mercaptopurine
If you take allopurinol with mercaptopurine, your dose of mercaptopurine must be reduced significantly, in order to prevent serious side effects of mercaptopurine.
 
Warfarin
Allopurinol may increase the level of warfarin in the blood, increasing the risk bleeding. Your healthcare provider should monitor you more closely when you start or stop allopurinol (or even when you change your allopurinol dose).
 

Final Thoughts on Drug Interactions With Allopurinol

It is possible that not all allopurinol drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
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Allopurinol Medication Information

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