Drug Interactions With Allopurinol

Certain medications may cause potentially serious drug interactions with allopurinol. When medications such as ACE inhibitors, antacids, and diuretics are taken with allopurinol, it can increase your risk of developing serious side effects. Allopurinol can also alter the amounts of certain medications in your blood. To reduce the risk of allopurinol drug interactions, make sure to tell your healthcare provider about all other medicines you are taking.

 

An Overview of Drug Interactions With Allopurinol

Allopurinol (Zyloprim®) can potentially interact with several other medications. Some of these medicines that may lead to allopurinol drug interactions include:
 
  • ACE inhibitors, including:

 

 

 

 

  • Mercaptopurine (Purinethol®)
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Allopurinol Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;