Methotrexate and Arava Drug Interaction

If you take Arava® (leflunomide) with methotrexate (Rheumatrex®, Trexall®), drug interactions may occur. Combining these medications may increase your risk for potentially serious complications, including liver problems. If your healthcare provider recommends taking these medications together, he or she will need to closely monitor you.
To minimize your risk of these and other potential drug interactions with Arava, make sure your healthcare provider is aware of any other prescription or nonprescription medications you are taking, as well as any herbal supplements or vitamins.
(Click Arava Drug Interactions for a complete list of other products that may negatively react with Arava. This article also describes what your healthcare provider may do to prevent a drug interaction between Arava and methotrexate.)
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