Arthritis Medications (Cont.)

Biologic Response Modifiers

Biologic response modifiers are the newest arthritis medications. These medications selectively block parts of the immune system called cytokines. Cytokines play a role in inflammation. These arthritis medications are highly effective at treating patients with an inadequate response to DMARDs. The long-term efficacy and safety of these drugs are uncertain.
 
The following are two common types of biologic response modifiers:
 
Tumor Necrosis Factor Inhibitors (Etanercept, Infliximab, Adalimumab)
There are several types of tumor necrosis factor (TNF) inhibitors used for arthritis treatment. Some examples of these drugs include:
 
Interleukin 1 Inhibitors (Anakinra)
Anakinra (Kineret®) is another biological response modifier type of rheumatoid arthritis medication. It is prescribed to people with moderate to severe rheumatoid arthritis to help decrease rheumatoid arthritis symptoms and slow the progression of structural damage. It may be recommended in people who have failed one or more DMARDs.
 
T Cell Costimulation Modulator (Abatacept)
Abatacept (Orencia®) is a new biologic response modifier used to treat moderate to severe rheumatoid arthritis in people who have not adequately responded to other rheumatoid arthritis medications.
 
(Arthritis Medications Continued: Page 6)

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Written by/reviewed by: Arthur Schoenstadt, MD
Last reviewed by: Arthur Schoenstadt, MD