Biologic Response ModifiersBiologic response modifiers are the newest medications for arthritis. These drugs selectively block parts of the immune system called cytokines. Cytokines play a role in inflammation. These medications are highly effective at treating people with an inadequate response to DMARDs. The long-term efficacy and safety of these drugs are uncertain.
The following are common types of biologic response modifiers:
- Tumor necrosis factor inhibitors (etanercept, infliximab, adalimumab)
- Interleukin-1 inhibitors (anakinra)
- T-cell costimulation modulator (abatacept).
Tumor Necrosis Factor Inhibitors (Etanercept, Infliximab, Adalimumab)
Several types of tumor necrosis factor (TNF) inhibitors are used for arthritis treatment. Some examples of these drugs include:
Interleukin-1 Inhibitors (Anakinra)
Anakinra (Kineret®) is prescribed to people with moderate to severe rheumatoid arthritis to help decrease symptoms and slow down the progression of structural damage. It may be recommended in people who have failed one or more DMARDs.
T Cell Costimulation Modulator (Abatacept)
Abatacept (Orencia®) is used to treat moderate to severe rheumatoid arthritis in people who have not adequately responded to other medications.