Biologic Response Modifiers
Biologic response modifiers are the newest
arthritis medications. These medications selectively block parts of the immune system called cytokines. Cytokines play a role in inflammation. These arthritis medications are highly effective at treating patients with an inadequate response to DMARDs. The long-term efficacy and safety of these drugs are uncertain.
The following are two common types of biologic response modifiers:
Tumor Necrosis Factor Inhibitors (Etanercept, Infliximab, Adalimumab)
There are several types of tumor necrosis factor (TNF) inhibitors used for
arthritis treatment. Some examples of these drugs include:
Interleukin 1 Inhibitors (Anakinra)
T Cell Costimulation Modulator (Abatacept)
Abatacept (
Orencia®) is a new biologic response modifier used to treat moderate to severe rheumatoid arthritis in people who have not adequately responded to other rheumatoid arthritis medications.