Drug Combinations With Arthrotec to Avoid

Cyclosporine
Cyclosporine may increase blood levels of Arthrotec, potentially increasing the risk for side effects. Taking these drugs together may also increase the risk for kidney problems. Talk with your healthcare provider before taking Arthrotec with cyclosporine.
 
CYP 2C9 Inducer Medications
The liver breaks down Arthrotec using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inducers can increase the activity of these enzymes. Thus, combining Arthrotec with one of these drugs may decrease the level of Arthrotec in your blood, potentially making it less effective. Talk to your healthcare provider before taking these medicines together.
 
CYP 2C9 Inhibitor Medications
The liver breaks down Arthrotec using enzymes known as CYP 2C9 enzymes, and medications known as CYP 2C9 inhibitors can decrease the activity of these enzymes. Thus, combining Arthrotec with one of these drugs may increase the level of Arthrotec in your blood, potentially increasing your risk for side effects. You may need to be monitored more closely if you take these medications together.
 
Digoxin
Arthrotec can increase the level of digoxin in the blood, possibly increasing your risk for potentially serious digoxin side effects. Your healthcare provider may need to check your digoxin blood level if you start or stop taking Arthrotec.
 
Diuretics
Arthrotec can decrease the effectiveness of diuretics. Talk to your healthcare provider before taking these medicines together.
 
Lithium
Taking Arthrotec and lithium together may increase the levels of lithium in your blood. Your healthcare provider may need to monitor you more closely and adjust your lithium dosage if you take these medicines together.
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Arthrotec Medication Information

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