Medications That Interfere With Arthrotec
"Blood Thinners" and Other Similar Drugs
Combining Arthrotec with anticoagulants, antiplatelet drugs, or other medications that increase the risk for bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not take these medicines together without first talking to your healthcare provider.
Diclofenac sodium may increase the risk of methotrexate toxicity. Do not combine these drugs without your healthcare provider's supervision and approval.
Oxytocin is a medication used to stimulate labor by causing contractions. Arthrotec contains misoprostol (Cytotec®), a medicine that can also cause uterine contractions. Thus, taking these medicines together may increase the effects of oxytocin on the uterus.
Arthrotec may increase pemetrexed blood levels, which could increase your risk for side effects. Your healthcare provider will monitor you more closely if you take these medicines together. If you have kidney disease, your healthcare provider may recommend you avoid taking Arthrotec two to five days before, the day of, and two days after you receive pemetrexed.
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with Arthrotec may increase the risk of GI bleeding. Check with your healthcare provider before taking Arthrotec with one of these drugs.
Voriconazole may increase the amount of Arthrotec in your blood, possibly increasing your risk for Arthrotec side effects. Your healthcare provider may recommend a lower Arthrotec dosage if you take voriconazole.