Arthrotec Drug Interactions

A variety of different medications may cause problems when used with Arthrotec. Some of these products include beta blockers, medications that thin the blood, and certain antacids that contain magnesium. Combining drugs such as these with Arthrotec can cause interactions that may lead to potentially serious side effects or decrease the effectiveness of the medications.

An Overview of Interactions With Arthrotec

Arthrotec® (diclofenac/misoprostol) can potentially react with a number of other medications. Some of the products that may lead to drug interactions with Arthrotec include but are not limited to:
  • ACE inhibitors, such as:
  • Angiotensin II receptor blockers (ARBs), such as:
  • Certain antacids
  • Corticosteroids, such as:
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
  • CYP 2C9 inhibitors, such as:
  • Lithium (Eskalith®, Eskalith CR®, Lithobid®)
  • Medications that "thin" the blood (anticoagulant and antiplatelet drugs), such as:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
  • Voriconazole (VFEND®).
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Arthrotec Medication Information

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