Products That Interfere With Celebrex

Celebrex Drug Interactions Explained

The following sections provide more detail on the potentially negative interactions that can occur when Celebrex is combined with any of the drugs listed above.
ACE Inhibitors
When ACE inhibitors and Celebrex are taken together, the effectiveness of the ACE inhibitor may be reduced. As a result, your healthcare provider may choose to adjust your dose of the ACE inhibitor as necessary or may recommend one of the Celebrex alternatives.
Angiotensin II Receptor Blockers (ARBs)
Celebrex may make ARBs less effective. Check with your healthcare provider before combining these medications.
Low-dose aspirin (81 mg) and Celebrex can be used together; however, studies have indicated that the risk of stomach ulcers is higher when these medicines are combined. Talk to your healthcare provider about drug interactions between aspirin and Celebrex in your particular situation.
Beta Blockers
Combining Celebrex with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
Bile Acid Sequestrants
Bile acid sequestrants can bind to Celebrex in the digestive tract and delay its absorption into the body. To avoid this drug interaction, Celebrex should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
Using corticosteroids with Celebrex can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
Celebrex may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
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