Cod Liver Oil Drug Interactions (Cont.)

Cod Liver Oil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when cod liver oil is combined with any of the drugs listed above.
 
Aspirin
Theoretically, taking aspirin with cod liver oil may increase the risk of bleeding. If you take these two products together, make sure to tell your healthcare provider if you develop any unusual bruising or bleeding.
 
Blood Pressure Medications
Taking cod liver oil with high blood pressure medications may decrease your blood pressure too much, possibly increasing the risk of low blood pressure (hypotension). Check with your healthcare provider before combining these two things, as he or she may need to monitor you more closely and adjust the dose of your blood pressure medication as necessary.
 
Clopidogrel (Plavix)
Clopidogrel may interact with cod liver oil, potentially increasing your risk of bleeding. However, the significance of this interaction is not yet known. Check with your healthcare provider before taking clopidogrel and cod liver oil together.
 
Heparin and Heparin-Like Products
Theoretically, taking heparin with cod liver oil may increase the risk of bleeding. Check with your healthcare provider before combining these products. If you know in advance that you will need to take heparin (such as for an upcoming surgery), it may be a good idea to temporarily stop taking cod liver oil.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Theoretically, taking an NSAID with cod liver oil may increase the risk of bleeding. If you take an NSAID regularly, you may want to check with your healthcare provider before also taking cod liver oil.
 
Vitamin A and Vitamin D
Cod liver oil contains a large dose of vitamin A and vitamin D -- much more than in most vitamins or supplements -- and it's enough to cause toxicity in some people. Taking additional vitamin A or vitamin D along with cod liver oil increases the risk of toxicity due to these vitamins.
(Cod Liver Oil Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;