Colchicine Dosage

Your healthcare provider will recommend a colchicine dosage based on several factors, such as your age, the condition being treated, and your liver function. In general, the standard dose for preventing gout attacks is one tablet once or twice daily. To treat gout attacks, the dosage is generally two tablets at the first sign of a flare, followed by another tablet one hour later.

An Introduction to Dosing With Colchicine

The dose of colchicine your healthcare provider recommends will vary, depending on various factors, such as:
 
  • The medical condition being treated
  • Your age
  • Your kidney and liver function
  • Other medications you are taking.
     
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.
 
It should be noted that the information from this article was taken from the prescribing information for Colcrys®, the only FDA-approved colchicine medication. It is different from the dosing information for unapproved colchicine products. However, the dosing information based on Colcrys is more thorough and up-to-date, and should generally be used in place of the older, unapproved dosing information.
 
If your healthcare provider recommends a dosage based on the older, unapproved dosing information, you may want to ask him or her if the current dosing guidelines would be a better option for you.
 

Dose of Colchicine for Gout

For preventing gout attacks, the standard colchicine dosage is one tablet once or twice daily.
 
For treating a gout attack, the standard dosage is two tablets (1.2 mg) at the first sign of a flare, followed by another tablet (0.6 mg) one hour later. Higher doses have not been found to be more effective. For people who are already taking colchicine for gout attack prevention, this treatment dose (two tablets followed by one an hour later) can still be used to treat an attack. The usual prevention dosage can then be continued, starting 12 hours later.
 
People with liver disease, kidney disease, or who are taking certain other medications may need a lower-than-normal dosage of colchicine.
 
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