Familial Mediterranean fever (FMF) is a genetic condition that is most common in people of Mediterranean descent. It causes recurrent attacks of peritonitis (inflammation of the lining of the abdomen), fever, arthritis, pleuritis (inflammation of the lining of the lungs and chest cavity), or various other problems.
People who have FMF typically experience their first attacks during childhood. The most serious complication of FMF is kidney failure. However, the use of colchicine appears to prevent the kidney damage caused by FMF. Colcrys was approved for FMF based on its ability to decrease the frequency of FMF attacks.
How Does It Work?It is thought that colchicine works for gout by limiting inflammation. Specifically, it is thought to inhibit certain inflammatory cells known as neutrophils that are responsible for some of the symptoms of gout.
It is unclear how exactly colchicine works for familial Mediterranean fever, although the inhibition of neutrophils or other inflammatory cells is probably involved.