Taking Diclofenac Sodium Extended-Release With Other Drugs

Diclofenac Sodium Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when the drugs mentioned above are combined with diclofenac sodium.
 
ACE Inhibitors
Diclofenac sodium extended-release might reduce the effectiveness of ACE inhibitors for lowering blood pressure and may also increase the risk of kidney damage. If you take diclofenac sodium extended-release with an ACE inhibitor, your healthcare provider should monitor your blood pressure to watch for this interaction.
 
ARBs
Combining diclofenac extended-release with an ARB can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the ARB for lowering blood pressure.
 
Beta Blockers
Combining diclofenac extended-release with a beta blocker may interfere with the beta blocker's ability to lower blood pressure. Check with your healthcare provider before taking these medications together.
 
Bile Acid Sequestrants
Bile acid sequestrants can bind to diclofenac extended-release in the digestive tract and delay its absorption into the body. To avoid this drug interaction, diclofenac extended-release should be taken at least one hour before or four to six hours after the bile acid sequestrant has been taken.
 
Corticosteroids
Using corticosteroids with diclofenac extended-release can increase the risk of bleeding. Your healthcare provider may choose to monitor you more closely or adjust your dose of these drugs.
 
Cyclosporine
Diclofenac extended-release may increase the level of cyclosporine in the blood, increasing the risk of serious cyclosporine side effects. In addition, this combination may increase the risk of kidney damage. Check with your healthcare provider before taking these medications together.
 
CYP 2C9 Inducers
The liver breaks down (metabolizes) this medication using certain enzymes known as CYP 2C9 enzymes. Several other medications, known as CYP 2C9 inducers, speed up these enzymes, potentially making diclofenac sodium-extended release less effective. Check with your healthcare provider before taking such medications together.
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Diclofenac Sodium Extended-Release Info

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