Diclofenac Sodium Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when the drugs mentioned above are combined with
diclofenac sodium.
Warfarin
If you are taking blood thinners, such as warfarin, while taking
diclofenac sodium extended-release, your body may metabolize them differently than intended. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust your dosages accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
Other Nonsteroidal Anti-Inflammatory Drugs
Using these pain relievers with diclofenac sodium extended-release can increase the risk of bleeding. However,
acetaminophen products (such as
Tylenol®) can be safely used.
Aspirin
Aspirin and diclofenac sodium extended-release can be used together; however, studies have indicated that when these medicines are combined, there is a greater risk of stomach ulcers. Talk with your healthcare provider about using aspirin and diclofenac sodium extended-release together in your particular situation.
ACE Inhibitors
Diclofenac sodium extended-release may inhibit the
blood pressure-lowering effects of ACE inhibitors. Your healthcare provider may need to adjust your dose of these drugs to prevent this interaction from occurring.
Diuretics
Diclofenac sodium extended-release may reduce the activity of diuretics. As a result, your healthcare provider may need to adjust your dose of these drugs.
Lithium
Taking diclofenac sodium extended-release and
lithium together may increase the levels of lithium in your body by decreasing the amount removed by the kidneys. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood to prevent negative interactions from occurring.
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