Drug Interactions With Diclofenac Sodium Extended-Release

If you are taking diclofenac sodium extended-release, interactions could occur if you combine the medication with products such as other nonsteroidal anti-inflammatory drugs (such as ibuprofen and naproxen) and corticosteroids (such as prednisone and hydrocortisone). Drug interactions can reduce the effectiveness of some medicines, raise the risk of stomach ulcers, and increase the risk of bleeding.

Interactions With Diclofenac Sodium Extended-Release: An Introduction

Diclofenac sodium extended-release (Voltaren®-XR) can potentially interact with a number of medicines. Some of these drug interactions can occur with the following medications:
 
 
  • Anticoagulant and antiplatelet drugs, such as:
     
    • Aspirin (Bayer® and others)
    • Cilostazol (Pletal®)
    • Clopidogrel (Plavix®)
    • Dipyridamole (Persantine®)
    • Eptifibatide (Integrilin®)
    • Heparin or heparin-like products, including dalteparin (Fragmin®), enoxaparin (Lovenox®), or tinzaparin (Innohep®)
    • Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
  • Lithium (Eskalith®, Lithobid®)
  • Methotrexate (Rheumatrex®, Trexall™).
      
Several herbal and nutritional supplements can also interact with diclofenac sodium extended-release and may increase the risk of bleeding. Examples of these include but are not limited to:
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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