Side Effects With Diclofenac Sodium Extended-Release

Constipation, stomach pain, and diarrhea are among the common side effects that have been reported with diclofenac sodium extended-release. Uncommon side effects include dry mouth, weight changes, and high blood pressure. Serious diclofenac sodium extended-release side effects that require emergency medical help include shortness of breath, slurred speech, and weakness on one part of your body.

Diclofenac Sodium Extended-Release Side Effects: An Introduction

As with any medicine, side effects are possible with diclofenac sodium extended-release (Voltaren®-XR); but not everyone who takes the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in many cases, they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with diclofenac sodium extended-release. Your healthcare provider can discuss a more complete list of side effects with you.)

Serious Side Effects of Diclofenac Sodium Extended-Release

As with any drug, there is the potential for serious side effects while taking diclofenac sodium extended-release. The U.S. Food and Drug Administration (FDA) warns that people using NSAIDs (nonsteroidal anti-inflammatory drugs), including diclofenac sodium extended-release, may be at higher risk for heart attack or stroke than those who do not take NSAIDs. This warning does not apply to those who take aspirin, however. This risk may be higher in people who have been taking NSAIDs for a long time. These events can occur without warning and can lead to loss of life. Call 911 if you experience any of the following symptoms:
  • Chest pain
  • Shortness of breath
  • Weakness on one part of your body
  • Slurred speech.
Other possibly serious side effects of diclofenac sodium extended-release include but are not limited to:
  • Allergic reactions, such as:
    • Swelling of the face or body
    • Blisters
    • Unexplained skin rash
    • Wheezing
    • Difficulty breathing
  • Stomach or intestinal problems, including:
    • Bleeding
    • Ulcers
    • A hole (known as a perforation)
  • Liver damage, which can cause:
    • Nausea
    • Fatigue
    • Yellowing of the skin or whites of the eyes (jaundice)
    • Excessive tiredness
    • Increased liver enzymes (found using a standard blood test)
  • Kidney problems, including kidney failure


Because diclofenac sodium extended-release can increase the risk of major or life-threatening bleeding, contact your healthcare provider immediately if you notice any unusual bleeding or have any of the following symptoms:
  • Bloody nose
  • Black, tarry stools
  • Blood in the urine or stools
  • Vomiting blood
  • Red or purple spots on the skin.
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Diclofenac Sodium Extended-Release Info

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