Diclofenac Drug Interactions

Some of the medications that may cause drug interactions with diclofenac products include cyclosporine, methotrexate, ACE inhibitors, and anticoagulant or antiplatelet drugs. These interactions could increase your risk for developing certain side effects or complications, such as internal bleeding or kidney damage.

An Overview of Diclofenac Interactions

Diclofenac can potentially interact with several other medications. Some of these medicines that may lead to drug interactions with diclofenac include:
 
  • ACE inhibitors, including:

 

 

  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including but not limited to:
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
  
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with diclofenac and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Top Foods to Fight Inflammation

Diclofenac Medication Information

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