Duexis

Duexis is a medicine prescribed to treat osteoarthritis and rheumatoid arthritis. It is a combination medicine that works by reducing inflammation and blocking histamine in the stomach. Because the medication contains famotidine, people taking it are less likely to develop ulcers during treatment. It comes in tablet form and is taken three times daily. Side effects may include nausea, heartburn, and diarrhea.

What Is Duexis?

Duexis™ (ibuprofen/famotidine) is a prescription medication approved for the treatment of osteoarthritis or rheumatoid arthritis; it can also help prevent stomach and upper intestinal ulcers. It contains a medication to relieve pain and inflammation (ibuprofen), along with an ingredient to reduce the risk of ulcers due to ibuprofen (famotidine).
 
(Click Duexis Uses for more information on this topic, including possible off-label uses.)
 

Who Makes This Medicine?

Duexis is made by Horizon Pharma USA, Inc.
 

How Does Duexis Work?

Duexis contains two different active ingredients. Ibuprofen belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). Like other NSAIDs, it works by blocking a specific enzyme known as cyclooxygenase (COX), blocking the production of various inflammatory substances in the body.
 
The other active ingredient (famotidine) is an H2 blocker that works by blocking a specific kind of histamine receptor. Histamine is a chemical released by the body that has several effects. In the stomach, histamine causes more acid to be produced. By blocking histamine in the stomach, famotidine reduces the amount of acid produced by the stomach. This is why famotidine is known as an "acid reducer" or "acid controller."
 
Ibuprofen is quite effective, but many people cannot take it because it has a tendency to cause ulcers. Famotidine is added to Duexis in order to help reduce the risk of ulcers.
 
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Duexis Medication Information

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