In clinical studies looking at the drug as a rheumatoid arthritis treatment, Enbrel was shown to improve symptoms of rheumatoid arthritis. More of the people taking it showed improvement compared to those who were not. During these studies, people usually noticed improvement within the first one or two weeks of treatment. Enbrel also improved the physical joint changes that occur in rheumatoid arthritis.
Other studies have shown that combining it with methotrexate (Rheumatrex®) improves the effectiveness of Enbrel for rheumatoid arthritis.
Juvenile Rheumatoid Arthritis
Another study looked at using Enbrel for the treatment of juvenile rheumatoid arthritis. In this study, 24 percent of the children and teenagers taking the drug experienced an arthritis flare, compared to 77 percent of those not taking it.
In a study of Enbrel for psoriatic arthritis, it was shown to reduce pain and other psoriatic arthritis symptoms, including stiffness in the morning. Also, while the physical joint changes in most of the people who were not taking the medication got worse, the joint changes in people who were taking it did not get worse.
Clinical studies have shown that Enbrel is effective for improving the symptoms of ankylosing spondylitis. The medication also improved the physical changes that occur with this condition.
In clinical studies for plaque psoriasis, Enbrel has been shown to improve the symptoms of plaque psoriasis. These studies did not include people with other types of psoriasis.