Enbrel (Cont.)

Enbrel Effects

Enbrel has been studied in several clinical trials for the following conditions:
 
Rheumatoid Arthritis
In clinical studies looking at Enbrel as a rheumatoid arthritis treatment, Enbrel was shown to improve symptoms of rheumatoid arthritis. More of the people taking Enbrel showed improvement compared to those people not taking Enbrel. During these studies, people usually noticed improvement within the first one or two weeks of taking Enbrel. Enbrel also improved the physical joint changes that occur in rheumatoid arthritis.
 
Other studies have shown that combining Enbrel with methotrexate (Rheumatrex®) improves the effectiveness of Enbrel for rheumatoid arthritis.
 
Juvenile Rheumatoid Arthritis
Another Enbrel study looked at using Enbrel for the treatment of juvenile rheumatoid arthritis. In this study, 24 percent of the children and teenagers taking Enbrel experienced an arthritis flare, compared to 77 percent of those not taking Enbrel.
 
Psoriatic Arthritis
In a study of Enbrel for psoriatic arthritis, Enbrel was shown to reduce pain and other psoriatic arthritis symptoms, including stiffness in the morning. Also, while the physical joint changes in most of the people who were not taking Enbrel got worse, the joint changes in people taking Enbrel did not get worse.
 
Ankylosing Spondylitis
Clinical studies have shown that Enbrel is effective for improving the symptoms of ankylosing spondylitis. Enbrel also improved the physical changes that occur with ankylosing spondylitis.
 
Plaque Psoriasis
In clinical studies for plaque psoriasis, Enbrel has been shown to improve the symptoms of plaque psoriasis. These studies did not include people with other types of psoriasis.
 
(Enbrel Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;