When certain medications are taken together, there is always the risk of developing negative drug interactions. With etodolac, medicines such as lithium, methotrexate, and digoxin can cause an adverse effect that may lead to serious complications. These drug interactions with etodolac can cause increased levels of the drugs in your system, stomach ulcers, bleeding, or kidney damage, among other things.
Corticosteroids, such as prednisone, hydrocortisone (Cortef®), dexamethasone (Decadron®, Dexone®, Hexadrol®), and others.
Several herbal and nutritional supplements can also interact with etodolac and may potentially increase the risk of bleeding. Examples of these include, but are not limited to: