Safety Issues With Flurbiprofen

Some Warnings and Precautions With Flurbiprofen

Some specific warnings and precautions to be aware of include the following:
 
To decrease the chances of developing these problems, it is recommended that people take the smallest effective dose for the shortest period of time. Also, call 911 if you notice things such as chest pain, shortness of breath, weakness, and slurring of speech.
  • All NSAIDs, including flurbiprofen, may cause or worsen high blood pressure. Flurbiprofen should be used with caution in people with known high blood pressure.
     
  • All NSAIDs, including flurbiprofen, may cause congestive heart failure or swelling. Make sure to contact your healthcare provider if you notice unexplained weight gain or swelling while taking flurbiprofen (see Ansaid and Weight Gain). Also, flurbiprofen should be used with caution in people with heart failure.
     
  • All NSAIDs, including flurbiprofen, have been reported to cause problems in the stomach and intestines, including bleeding (known as gastrointestinal bleeding), stomach ulcers, or holes in the stomach or intestines. These problems can lead to serious complications or even loss of life. Extreme caution should be used if flurbiprofen is prescribed to people with a history of ulcers or gastrointestinal bleeding.
To decrease the chances of developing these problems, it is recommended that people take the smallest effective dose for the shortest period of time. Make sure to contact your healthcare provider immediately if you experience any signs or symptoms of stomach ulcers or bleeding, including:
 
    • Abdominal pain (or stomach pain)
    • Indigestion
    • Black, tarry stools
    • Vomiting blood.
  • People taking NSAIDs, including flurbiprofen, can suffer kidney damage. It is more common in the elderly and people with kidney disease, heart failure, or liver problems. It is also more common in those taking diuretics or ACE inhibitors.
      
  • Liver damage can occur in people who are taking flurbiprofen. Contact your healthcare provider immediately if you notice things such as nausea, tiredness, lethargy, itchy or yellowing skin, abdominal pain (or stomach pain), or flu-like symptoms while taking flurbiprofen.
     
  • NSAIDs, including flurbiprofen, have been reported to cause allergic reactions. Seek emergency medical attention immediately if you notice things such as hives, unexplained rash, difficulty breathing, or swelling of the face and throat.
     
  • In rare cases, people taking flurbiprofen can develop a very serious rash. If you notice an unexplained rash or blisters, fever, or itchy skin, stop taking the flurbiprofen and call your healthcare provider.
     
  • If you are an alcoholic or drink alcohol frequently, discuss this with your healthcare provider prior to starting flurbiprofen. Alcohol can affect the way the liver works, indirectly affecting the flurbiprofen.
     
  • NSAIDs have been known to cause an increase in liver enzymes. Therefore, it is recommended that you have a blood test that looks at your liver function before starting flurbiprofen and 12 weeks after treatment has started.
     
  • Flurbiprofen has been known to cause anemia. If you are taking flurbiprofen for an extended amount of time and show signs of anemia, talk with your healthcare provider.
     
  • Problems with vision have been reported in people taking flurbiprofen. If you notice any changes in your vision, such as blurry vision or changes in color vision, contact your healthcare provider.
     
  • You should not take flurbiprofen with any other NSAIDs, as this may increase your risk of any of the problems discussed above. There are many NSAIDs available with or without a prescription, so make sure to read labels carefully. Some examples of NSAIDs include: ibuprofen (Motrin®, Advil®), naproxen (Naprosyn®), naproxen sodium (Aleve®, Anaprox®, Naprelan®), diclofenac (Cataflam®, Voltaren®), indomethacin (Indocin®), nabumetone (Relafen®), oxaprozin (Daypro®), celecoxib (Celebrex®), meloxicam (Mobic®), etodolac (Lodine®), ketoprofen, ketorolac (Toradol®), and others. You can ask your doctor or pharmacist for a complete list of these medications.
     
  • Flurbiprofen is a pregnancy Category C medicine, meaning that it could potentially cause harm to your unborn child. If you are pregnant, you should take flurbiprofen only if the benefits outweigh the possible risks to your unborn child. Flurbiprofen is not recommended for women in the third trimester of pregnancy because it can cause injury and even death to the developing fetus. If you become pregnant while taking Flurbiprofen, contact your healthcare provider immediately (see Ansaid and Pregnancy for more information).
     
  • If you are nursing, it is recommended that you not take flurbiprofen. Therefore, if you are nursing and taking flurbiprofen, discuss with your healthcare provider whether to stop nursing or discontinue the medicine.
     
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