Important Instructions for Gengraf

General Information on Taking Gengraf

Some considerations to keep in mind during treatment with Gengraf include the following:
  • This medication comes in the form of a capsule and a liquid solution. It is taken by mouth twice a day.
  • Gengraf contains a modified form of cyclosporine, which has been slightly changed from regular cyclosporine (Sandimmune) and is more easily absorbed into the body. For this reason, Gengraf and original cyclosporine are not interchangeable. If you need to switch from one type or brand of cyclosporine to another, only do so under your healthcare provider's supervision. He or she may need to adjust your dosage.
  • You can take a dose with food or on an empty stomach; however, you should take it the same way every day, at the same time each day, and with the same amount of time between doses and meals.
  • The liquid solution should be mixed with room-temperature apple or orange juice to make the medicine more palatable. Mix the medicine immediately before drinking it using a glass container (not plastic). After drinking the medicine, add a little more juice to the glass and drink again to make sure you swallow your complete dose.
  • Do not mix the liquid solution with milk or grapefruit juice. Milk or grapefruit juice may alter the amount of medicine that is absorbed into your body. In addition, Gengraf is quite unpalatable when mixed with milk.
  • Always use the dosing syringe that came with your medicine to measure out your liquid dosage. When finished, wipe the syringe clean with a towel, but do not rinse it. Exposing the syringe to water may make it less accurate. If the syringe gets wet, let it dry completely before using it again.
  • For the medication to work properly, it must be taken as prescribed. Do not stop taking this medicine, or change to another brand of cyclosporine, without first talking to your healthcare provider.
  • If you are unsure about anything related to dosing with Gengraf, please talk with your healthcare provider, nurse, or pharmacist.
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