Gengraf Dosage

The condition being treated plays a large role in a person's dose of Gengraf, although other factors are also considered. For example, when treating rheumatoid arthritis, a person's weight is used to calculate the dose; when used to prevent transplant rejection, the type of organ received and blood levels of Gengraf play a role. When using the liquid form, mix it with apple or orange juice only.

An Introduction to Dosing With Gengraf

The dosage of Gengraf® (cyclosporine) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The reason you are taking the medicine
  • How you respond to it
  • Your weight
  • Your blood levels of Gengraf
  • Other medications you may be taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Gengraf Dosage for Preventing Transplant Rejection

The initial dose of Gengraf for prevention of transplant rejection is highly individual, and will depend on your weight, the organ you received, and other antirejection medicines you take. Treatment may begin 4 to 12 hours prior, immediately after, or a few days after (usually in the case of kidney transplant) the transplantation surgery.
Gengraf is normally given with other medicines, including a corticosteroid such as prednisone. The corticosteroid is usually started at a higher dosage and slowly tapered over a couple of months to a maintenance dose.
The initial Gengraf dosage will be adjusted based on your blood levels of the medication. Your healthcare provider will also consider any side effects you are experiencing and how well the medicine is working when adjusting your dose.
The goal is to find the best possible dosage for you to prevent transplant rejection while avoiding potentially serious or bothersome side effects. If you require long-term treatment, your healthcare provider will gradually adjust the amount to the lowest effective dose of Gengraf.
If you are being switched from original cyclosporine (Sandimmune®) to Gengraf, your initial dosage will likely be the same as your current original cyclosporine dosage. Your healthcare provider will monitor your blood levels once or twice a week (more often in some people), and adjust your dose until your blood levels are within the desired range. Your healthcare provider may also adjust this amount if you experience side effects.
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Gengraf Drug Information

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