Combining Other Products With Gengraf

CYP 3A4 Inhibitor Medications
The body breaks down Gengraf using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Gengraf with one of these drugs may increase the level of Gengraf in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together.
 
Dabigatran
Combining Gengraf with dabigatran could increase your dabigatran blood levels and your risk for bleeding. Talk to your healthcare provider before combining these medicines. He or she may want to monitor you more closely or give you a lower dabigatran dosage.
 
Digoxin
Gengraf may increase the level of digoxin in your body, which could increase your risk for serious digoxin side effects. Your healthcare provider will need to monitor you closely if you take these medicines together.
 
Echinacea
Echinacea could decrease the effectiveness of Gengraf. Do not take echinacea while taking this drug without first talking with your healthcare provider.
 
Fentanyl
Combining Gengraf with fentanyl could cause your fentanyl blood levels to increase to potentially unsafe levels. If your levels become too high, you may experience serious fentanyl side effects, including dangerously slow and shallow breathing. If you take these medicines together, your healthcare provider should monitor you closely for problems, especially when you first start taking Gengraf.
 
Grapefruit Juice
Do not consume grapefruit juice during treatment with Gengraf. Grapefruit juice may increase the amount of Gengraf in your body, potentially increasing your risk for serious side effects.
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