More Medicines That React With Gengraf

Live Vaccinations
You should not receive live vaccinations during treatment with Gengraf. Other vaccines may be less effective during this time. Therefore, talk to your healthcare provider before you receive any vaccination or immunization while taking this drug.
 
Methotrexate
People taking Gengraf for psoriasis should not combine it with methotrexate, due to the increased risk of skin cancer.
 
Methylprednisolone
There have been reports of seizures in people taking Gengraf, especially when used in combination with methylprednisolone. There have also been reports of encephalopathy, a medical term for a disease of the brain that causes altered brain function. Seek immediate medical care if you experience possible signs of encephalopathy, such as:
 
  • Confusion
  • Vision changes
  • Muscle weakness
  • Problems with movement
  • Seizures.
     
Natalizumab
Combining Gengraf with natalizumab may increase your risk for potentially serious infections. In general, these medications should not be taken together.
 
Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Taking Gengraf with an NSAID may increase your risk for kidney problems. Your healthcare provider may need to monitor your kidneys more closely if you start taking an NSAID, or have an increase in your NSAID dose, during Gengraf treatment.
 
Orlistat
Orlistat may decrease the amount of Gengraf absorbed from your gut into your body, which could make the medicine less effective. You should not take these medications together.
 
P-Glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of body tissues so they can be excreted through the urine or feces. Pgp helps remove Gengraf from the body, and medications known as Pgp inducers increase the activity of Pgp.
 
Taking Gengraf with one of drugs causes Gengraf to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor your Gengraf blood levels more closely if you take it with a Pgp inducer, and adjust your dose as needed.
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Gengraf Drug Information

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