Drug Combinations With Gengraf to Avoid

P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of the tissues so they can be excreted through the urine or feces. Pgp helps remove Gengraf from the body, and medications known as Pgp inhibitors decrease the activity of Pgp.
 
Thus, taking Gengraf with one of these Pgp inhibitors causes Gengraf to be removed from the body more slowly, potentially increasing Gengraf blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together and lower your dose if needed.
 
Pimecrolimus
Taking Gengraf with pimecrolimus may increase your risk for potentially serious side effects, including infection and skin cancer. Although the risk for these serious side effects is generally rare, it is also recommended that pimecrolimus not be used with medicines that weaken the immune system, including Gengraf.
 
Potassium-Sparing Diuretics
Combining potassium-sparing diuretics with Gengraf increases the risk of high blood potassium levels (hyperkalemia). In general, these medicines should not be taken together.
 
Silodosin
Gengraf may increase the amount of silodosin in your blood, increasing your risk for side effects. It is generally recommended that these medicines not be used together.
 
Statin Medications
Gengraf may increase blood levels of statin medicines, possibly increasing the risk for serious statin side effects. Gengraf should not be taken with simvastatin or pitavastatin. Other statins may require a dosage reduction if taken with Gengraf.
 
Tacrolimus
Taking Gengraf with tacrolimus may increase your risk for potentially serious side effects, including infection and skin cancer. Although the risk for these serious side effects is rare, it is generally recommended that tacrolimus not be used with medicines that weaken the immune system, such as Gengraf.
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