Gengraf Overdose

The effects of an overdose with Gengraf (cyclosporine) can vary, based on extenuating circumstances; however, in general, problems can include drowsiness, headache, vomiting, and increased heart rate and blood pressure, among other things. Treatment is likely to involve relieving the specific symptoms that have occurred (possibly through IV fluids or activated charcoal) and monitoring a person's vital signs.

Can You Take Too Much Gengraf?

Gengraf® (cyclosporine) is a prescription medication used to prevent transplant rejection and to treat certain people with psoriasis or rheumatoid arthritis. As with any medicine, it is possible to take too much Gengraf.
The specific effects of an overdose would likely vary, depending on a number of factors, including how much of the medicine was taken and whether it was taken with any other medications or substances.

Effects of a Gengraf Overdose

Based on reports of overdoses with Gengraf, taking too much may cause the following symptoms:
  • Nausea
  • Vomiting
  • Drowsiness
  • Headache
  • Increased heart rate (tachycardia)
  • Kidney problems (these are usually temporary)
  • Increased blood pressure (hypertension)
  • Changes in taste
  • Flushing of the face
  • Burning sensation in the mouth or on the skin
  • Sore gums
  • Muscle twitch
  • Tremor
  • Swelling of the stomach, arms, legs, ankles, or feet
  • Confusion or altered consciousness
  • Seizure
  • An abnormal heart rhythm (arrhythmia).

Treatment Options

The treatment for a Gengraf overdose may vary. If the overdose was recent, a healthcare provider may administer activated charcoal or "pump the stomach" to help reduce the amount of medicine absorbed into the bloodstream. Dialysis is not expected to be helpful in removing Gengraf from the body.
Treatment for any type of overdose also usually involves supportive care. This consists of treating the symptoms that occur as a result of the overdose. Supportive treatment for a Gengraf overdose may include:
  • Fluids through an intravenous line (IV), if necessary
  • Close monitoring of kidney function, body salts (electrolytes), blood pressure, and heart rhythm
  • Medications to treat seizures, if they occur.
It is important to seek medical attention immediately if you or someone else may have overdosed on this medication.
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