Gengraf Side Effects

Approximately 55 percent of people taking Gengraf in clinical studies reported tremors as a possible side effect. Other adverse reactions include kidney problems, headache, and infection. Potentially serious side effects are also possible, such as skin discoloration, breathing problems, and painful urination. If you experience these or any other type of problem with Gengraf, contact your healthcare provider right away.

An Introduction to Gengraf Side Effects

Just like any medicine, Gengraf® (cyclosporine) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Gengraf. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Gengraf

Gengraf has been studied extensively in clinical trials. In these studies, the side effects reported in a group of people taking Gengraf or another cyclosporine medication (Sandimmune®) were carefully documented, and (in some studies) compared to the side effects reported in a group of people taking placebo (a "sugar pill" with no active ingredients).
As a result, it was possible to see what side effects occurred, how often they occurred, and how they compared to the placebo. In these studies, the adverse reactions observed in people taking Gengraf were similar to those observed in people taking Sandimmune.
Based on these clinical studies, the most commonly expected Gengraf side effects include but are not limited to:
  • Tremor -- in up to 55 percent of people
  • High blood pressure (hypertension) -- up to 53 percent
  • Excessive dark and coarse facial or body hair growth -- up to 45 percent
  • Kidney problems -- up to 38 percent
  • Headache -- up to 25 percent
  • Infection of any kind -- up to 25 percent
  • Nausea -- up to 18 percent
  • Overgrowth of gum tissue -- up to 16 percent
  • Abdominal pain (stomach pain) -- up to 15 percent
  • High triglycerides (a type of fat found in the blood) -- up to 15 percent
  • Body pain -- up to 13 percent
  • Diarrhea -- up to 13 percent
  • Leg cramps -- up to 12 percent
  • Tingling, pricking, or numbing sensation of the skin -- up to 11 percent.
Other common side effects of Gengraf, occurring in 3 to 10 percent of people, included but are not limited to:
  • Swelling (edema) of the body
  • Vomiting
  • Rash
  • Heartburn or indigestion
  • Dizziness
  • Stuffy nose
  • Coughing
  • Shortness of breath
  • Sudden warmth and redness of the face and neck (flushing)
  • Acne
  • Chest pain
  • Breast enlargement
  • Joint or muscle pain
  • Fatigue
  • Gas
  • Hair loss (alopecia)
  • Insomnia
  • Flu-like symptoms
  • Migraine
  • Uncontrollable shaking
  • Cramps
  • Decreased appetite
  • Increased sensitivity to touch.
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Gengraf Drug Information

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