Specific Products for Gout

Allopurinol (Zyloprim)
Allopurinol is a type of gout medicine used to slow the rate at which the body produces uric acid. Allopurinol has been approved for the treatment of gout and is frequently prescribed to gout patients who have uric acid kidney stones or other kidney problems.
 
Side effects of allopurinol include skin rash and an upset stomach, both of which usually subside as the body becomes used to the drug. Allopurinol makes some people drowsy, so people taking the drug should be careful about driving or operating heavy machinery until they know how the drug affects them.
 
Probenecid (Benemid) and Sulfinpyrazone (Anturane)
Both of these medications increase the amount of uric acid removed in urine (known as uricosuric drugs). In addition to lowering blood uric acid levels, these drugs help dissolve deposits of uric acid crystals around joints and in other tissue.
 
Probenecid and sulfinpyrazone can cause nausea, stomach upset, headache, and a potentially serious skin rash.
 
Febuxostat (Uloric)
Febuxostat is the first new medication approved for gout in the past 40 years. Febuxostat works by lowering uric acid levels. Studies have consistently shown that febuxostat lowers uric acid levels in the blood more effectively than allopurinol.
 
For instance, one study looked at the percentage of people who were able to lower their uric acid levels to 6 mg/dL or lower. As many as 74 percent of people taking Uloric 80 mg achieved this goal, compared to just 36 percent of people who were taking allopurinol.
 
Side effects of febuxostat include nausea and joint pain (see Uloric Side Effects for more information).
 

Pegloticase (Krystexxa)

Pegloticase is a prescription medication approved for preventing gout attacks. It is reserved for "refractory" cases of gout (for use in people who have not responded adequately to other gout medications). It is given by IV once every two weeks.

 

Pegloticase lowers uric acid levels by encouraging a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.

 

Pegloticase works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, pegloticase is usually taken along with other gout medications, at least temporarily. 

 
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