Ibuprofen Drug Interactions

Some of the drugs that can potentially interact with ibuprofen include aspirin, lithium, and diuretics. Ibuprofen has also been known to interact with a number of herbal and nutritional supplements to increase your risk of bleeding. Certain drug interactions can increase your risk of stomach ulcers; others may change the way your body metabolizes some medicines, and cause some drugs to be less effective.

• Angiotensin-converting enzyme inhibitors (ACE inhibitors), including:
   
  • Benazepril (Lotensin^®), benazepril-hydrochlorothiazide (Lotensin HCT^®), or benazepril-amlodipine (Lotrel^®)
  • Captopril (Capoten^®) or captopril-hydrochlorothiazide (Capozide^®)
  • Enalapril (Vasotec^®), enalapril-hydrochlorothiazide (Vaseretic^®), or enalapril-felodipine (Lexxel^®)
  • Fosinopril (Monopril^®) or fosinopril-hydrochlorothiazide (Monopril-HCT^®)
  • Lisinopril (Prinivil^®, Zestril^®) or lisinopril-hydrochlorothiazide (Prinzide^®, Zestoretic^®)
  • Quinapril (Accupril^®) or quinapril-hydrochlorothiazide (Accuretic^®, Quinaretic™)
  • Ramipril (Altace^®)

• Angiotensin II receptor blockers (ARBs), such as:

• • Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
  • Candesartan (Atacand^®) or candesartan-hydrochlorothiazide (Atacand HCT^®)
  • Eposartan (Teveten^®) or eposartan-hydrochlorothiazide (Teveten^® HCT)
  • Irbesartan (Avapro^®) or irbesartan-hydrochlorothiazide (Avalide^®)
  • Losartan (Cozaar^®) or losartan-hydrochlorothiazide (Hyzaar^®)
  • Olmesartan (Benicar^®), olmesartan-hydrochlorothiazide (Benicar HCT^®), or amlodipine and olmesartan (AZOR™)
  • Telmisartan (Micardis^®) or telmisartan-hydrochlorothiazide (Micardis^® HCT)
  • Valsartan (Diovan^®) or valsartan-hydrochlorothiazide (Diovan HCT^®)

• Beta blockers, such as:
   
  • Acebutolol (Sectral^®)
  • Atenolol (Tenormin^®)
  • Betaxolol (Kerlone^®)
  • Bisoprolol (Zebeta^®)
  • Carvedilol (Coreg^®, Coreg CR^®)
  • Esmolol (Brevibloc^®)
  • Labetalol (Trandate^®)
  • Metoprolol (Lopressor^®, Toprol-XL^®)
  • Nadolol (Corgard^®)
  • Nebivolol (Bystolic^®)
  • Penbutolol (Levatol^®)
  • Propranolol (Inderal^®, Inderal^® LA, InnoPran XL™)
  • Sotalol (Betapace^®)
  • Timolol

• Bile acid sequestrant cholesterol medications, including:
   
  • Cholestyramine (Prevalite^®, Questran^®, Questran^® Light)
  • Colesevelam (WelChol^®)
  • Colestipol (Colestid^®)

• Corticosteroids, including (but not limited to):
   
  • Betamethasone (Celestone^®)
  • Cortisone
  • Dexamethasone (Decadron^®)
  • Fludrocortisone (Florinef^®)
  • Hydrocortisone (Cortef^®)
  • Methylprednisolone (Depo-Medrol^®, Medrol^®)
  • Prednisolone (Orapred^®, Pediapred^®)
  • Prednisone
  • Triamcinolone (Kenalog^®, Aristospan^®)

• Cyclosporine (Gengraf^®, Neoral^®, Sandimmune^®)
• Digoxin (Digitek^®, Lanoxin^®)
• Diuretics, such as:
   
  • Amiloride (Midamor^®) or amiloride-HCTZ (Moduretic^®)
  • Bumetanide (Bumex^®)
  • Chlorothiazide (Diuril^®)
  • Chlorthalidone (Thalitone^®)
  • Ethacrynic acid (Edecrin^®)
  • Furosemide (Lasix^®)
  • Hydrochlorothiazide (Esidrix^®, HydroDIURIL^®, Microzide^®, Oretic^®)
  • Metolazone (Zaroxolyn^®)
  • Spironolactone (Aldactone^®) or spironolactone-HCTZ (Aldactazide^®)
  • Torsemide (Demadex^®)
  • Triamterene (Dyrenium^®) or triamterene/HCTZ (Dyazide^®, Maxzide^®)

• Lithium (Eskalith^®, Lithobid^®)
• Medications that "thin" the blood or otherwise increase bleeding risk (such as anticoagulant and antiplatelet drugs), such as:
   
  • Antithrombin (ATryn^®, Thrombate III^®)
  • Apixaban (Eliquis^®)
  • Argatroban
  • Aspirin (Bayer^® and others)
  • Bivalirudin (Angiomax^®)
  • Cilostazol (Pletal^®)
  • Clopidogrel (Plavix^®)
  • Dabigatran (Pradaxa^®)
  • Dipyridamole (Persantine^®)
  • Drotrecogin alfa (Xigris^®)
  • Eptifibatide (Integrilin^®)
  • Fondaparinux (Arixtra^®)
  • Heparin or heparin-like products, including dalteparin (Fragmin^®), enoxaparin (Lovenox^®), or tinzaparin (Innohep^®)
  • Lepirudin (Refludan^®)
  • Other nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

• • • Celecoxib (Celebrex^®)
    • Diclofenac (Cambia™, Cataflam^®, Flector^®, Solaraze^® Gel, Voltaren^®, Voltaren^® Gel, Voltaren^®-XR, Voltaren Ophthalmic^®, Zipsor™)
    • Etodolac (Lodine^®, Lodine^® XL)
    • Indomethacin (Indocin^®, Indocin SR^®)
    • Ketoprofen (Orudis^®, Actron^®, Oruvail^®)
    • Ketorolac (Toradol^®)
    • Meloxicam (Mobic^®)
    • Nabumetone (Relafen^®)
    • Naproxen (Naprosyn^®) or naproxen sodium (Aleve^®, Anaprox^®, Naprelan^®)
    • Oxaprozin (Daypro^®)
    • Piroxicam (Feldene^®)
    • Others (see List of NSAIDs for a more complete list of these medications)

• • Pentoxifylline (Trental^®)
  • Prasugrel (Effient^®)
  • Rivaroxaban (Xarelto^®)
  • Thrombolytics, such as:

• • • Alteplase (Activase^®)
    • Reteplase (Retavase^®)
    • Streptokinase (Streptase^®)
    • Tenecteplase (TNKase^®)

• • Ticagrelor (Brilinta^®)
  • Ticlopidine (Ticlid^®)
  • Tirofiban (Aggrastat^®)
  • Warfarin (Coumadin^®, Jantoven^®)

• Methotrexate (Rheumatrex^®, Trexall^®)
• Probenecid
• SSRI or SNRI medications, including:
   
  • Citalopram (Celexa^®)
  • Duloxetine (Cymbalta^®)
  • Desvenlafaxine (Pristiq^®)
  • Escitalopram (Lexapro^®)
  • Fluoxetine (Prozac^®, Sarafem^®, Selfemra™)
  • Fluvoxamine (Luvox^®, Luvox^® CR)
  • Levomilnacipran (Fetzima™)
  • Milnacipran (Savella™)
  • Paroxetine (Paxil^®, Paxil CR^®, Pexeva^®, Brisdelle™)
  • Sertraline (Zoloft^®)
  • Venlafaxine (Effexor^®, Effexor XR^®).

• Dong quai
• Feverfew
• Garlic
• Ginger
• Ginkgo biloba
• Ginseng
• St. John's wort
• Fish oil supplements.