Ibuprofen Drug Interactions

Some of the drugs that can potentially interact with ibuprofen include aspirin, lithium, and diuretics. Ibuprofen has also been known to interact with a number of herbal and nutritional supplements to increase your risk of bleeding. Certain drug interactions can increase your risk of stomach ulcers; others may change the way your body metabolizes some medicines, and cause some drugs to be less effective.

An Overview of Ibuprofen Interactions

 Ibuprofen (marketed under brand names such as Motrin®, Advil®, Genpril®, and Nuprin®) can potentially interact with a number of medicines. Some of these medications include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with ibuprofen and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Ibuprofen Drug Interactions Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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