Imuran Dosage

Factors that can affect your dose of Imuran include the medical condition being treated, how your body responds to the drug, and your weight. The recommended starting dosage for preventing rejection after a kidney transplant is 3 mg to 5 mg per kg once daily. For treating rheumatoid arthritis, the starting dose is Imuran 1 mg per kg daily (taken at once or divided into two smaller doses).

Imuran Dosage: An Overview

The dose of Imuran® (azathioprine) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • How your body responds to Imuran (some people do not clear the drug from the body as well as others)
  • Your weight
  • Other medical conditions you may have
  • Other medications you may be currently taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so. People with poor kidney function may need lower Imuran dosages. Also, a test can be done to see if you have low levels of thiopurine S-methyl transferase (TSMT), an enzyme that helps clear Imuran from the body. If you have low TSMT levels, you will need a low dose (or a different medication altogether) in order to prevent serious side effects.

Dose of Imuran for Kidney Transplantation

The recommended starting dose of Imuran for preventing kidney transplant rejection is Imuran 3 mg to 5 mg per kg (about 1.4 mg to 2.3 mg per pound) once daily, starting the day of (or sometimes a few days before) the transplant. Your healthcare provider may decrease your dose to Imuran 1 mg to 3 mg per kg (about 0.45 mg to 1.4 mg per pound) once daily if you are doing well.

What Is the Dose for Rheumatoid Arthritis?

The recommended starting dosage for rheumatoid arthritis treatment is Imuran 1 mg per kg (about 0.45 mg per pound) per day, usually between 50 mg to 100 mg per day. It can be taken once daily or split up into two doses per day. After eight weeks, your healthcare provider may increase your Imuran dose, if necessary.
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