Imuran Drug Interactions

More Information on Drug Interactions With Imuran

The following sections explain in detail the potentially negative interactions that can occur when Imuran is combined with any of the drugs listed above.
Allopurinol inhibits one of the enzymes that helps to remove Imuran from the body. If you take allopurinol and Imuran together, your healthcare provider should reduce your Imuran dosage to about one-third to one-fourth of the usual dose.
Aminosalicylates can increase the level of Imuran in your blood, potentially increasing the risk of Imuran side effects. Your healthcare provider may need to decrease your Imuran dosage to prevent this interaction from occurring.
Angiotensin-Converting Enzyme Inhibitors
Combining an ACE inhibitor with Imuran can increase your risk of anemia or leukopenia (low levels of certain white blood cells called leukocytes). Talk to your healthcare provider before taking these medications together.
There have been reports of a very aggressive and fatal form of cancer known as hepatosplenic T-cell lymphoma in people who took Imuran with infliximab, especially in young males being treated for Crohn's disease or ulcerative colitis. You and your healthcare provider should carefully discuss this risk before combining these two medications.
Sulfamethoxazole and Trimethoprim
Taking Imuran with sulfamethoxazole and trimethoprim can increase your risk of leukopenia. Talk to your healthcare provider before taking these medications together.
Imuran may decrease the effectiveness of warfarin, potentially increasing your risk of blood clots. Your healthcare provider should monitor you closely in this case and adjust your warfarin dosage as necessary.
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Imuran Drug Information

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