More Detail on Indomethacin Drug Interactions
The following sections explain in detail how the drugs mentioned above can cause potentially negative interactions when combined with
indomethacin.
Other Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Using these pain relievers with indomethacin can increase the risk for bleeding. Generally, it is safe to use
acetaminophen (
Tylenol®) products with indomethacin.
Aspirin
Studies have indicated that when people use aspirin and indomethacin together, the chances are higher for stomach ulcers or other problems in
digestive system. Aspirin has also been shown to decrease the levels of indomethacin in the blood. Talk to your healthcare provider about potential benefits and risks of using indomethacin and aspirin together in your situation.
Warfarin (Coumadin, Jantoven)
If you are taking blood thinners, such as warfarin, while taking indomethacin, your body may metabolize them differently than intended. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
ACE Inhibitors (Accupril, Lotensin, Vasotec, Altace)
Indomethacin may inhibit the
blood pressure-lowering effects of ACE inhibitors. Your healthcare provider may need to adjust your dose of these drugs.
Beta Blockers
Indomethacin may inhibit the blood pressure-lowering effects of beta blockers. Your healthcare provider may need to adjust your dose of these drugs.
Diuretics (Torsemide [Demadex], Furosemide [Lasix], Hydrochlorothiazide)
Indomethacin may reduce the activity of diuretics. Your healthcare provider may need to adjust your dose of these drugs.
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