Products That React With Indomethacin

Digoxin
Indomethacin may increase the level of digoxin in your bloodstream, increasing the risk of dangerous digoxin side effects. If you are taking digoxin, check with your healthcare provider before starting or stopping indomethacin.
 
Diuretics
Combining indomethacin with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking indomethacin and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining indomethacin with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine indomethacin with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Indomethacin may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Combining probenecid and indomethacin may increase the levels of indomethacin in the blood. Therefore, your healthcare provider may recommend a lower indomethacin dosage and monitor you more closely.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with indomethacin may increase the risk of bleeding. Check with your healthcare provider before taking indomethacin with an SSRI or SNRI.
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