Indomethacin Side Effects (Cont.)

Serious Indomethacin Side Effects

As with any drug, there is the potential for serious side effects. The U.S. Food and Drug Administration (FDA) warns that people using indomethacin or other NSAIDs (with the exception of aspirin) may have a higher risk of having a heart attack or stroke than those who do not take NSAIDs. This risk may be higher in people who have been taking NSAIDs for a long time. These events can occur without any warning and can lead to loss of life. Get emergency medical help by calling 911 as soon as possible if you experience any of the following symptoms:
 
  • Chest pain
  • Shortness of breath
  • Weakness on one part of your body
  • Slurred speech.
     
Other possible serious side effects of indomethacin include, but are not limited to:
 
  • Allergic reactions such as swelling of the face or body, blisters, unexplained skin rash, wheezing, or difficultly breathing
  • Stomach or intestine problems, including bleeding, ulcers, or a hole (known as a perforation)
  • Liver damage, which can cause nausea, fatigue, yellowing of the skin or whites of the eyes, and excessive tiredness
  • Increased liver enzymes, which may be a sign of liver failure or hepatitis
  • Kidney problems, including kidney failure
  • Fluid retention or unexplained weight gain
  • Congestive heart failure
  • Blurred vision.
     
Because indomethacin can increase the causes for major or life-threatening bleeding, contact your doctor immediately if you notice any unusual bleeding or have any of the following symptoms:
 
  • Bloody nose
  • Black, tarry stools
  • Blood in the urine or stools
  • Vomiting blood
  • Red or purple spots on the skin.
     
(Indomethacin Side Effects Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;