Kineret Uses

Using Kineret for NOMID

Cryopyrin-associated periodic syndromes (CAPS) are a group of rare hereditary conditions, including:
  • Familial cold autoinflammatory syndrome (FCAS)
  • Muckle-Wells syndrome (MWS)
  • Neonatal-onset multisystem inflammatory disease (NOMID).
NOMID is the most severe form of CAPS. Symptoms usually begin at birth, are progressive, and can lead to severe complications, such as hearing loss, vision loss, joint damage, and death. Studies suggest that Kineret actually halts the organ damage caused by NOMID.
Kineret is approved to treat NOMID in both children and adults.

How Does Kineret Work?

People with rheumatoid arthritis often have high levels of a certain protein called interleukin-1 (IL-1) in their joints. IL-1 causes inflammation, cartilage damage, and bone erosion. Kineret is a synthetic form of a different naturally occurring protein in the body that inhibits the effects of IL-1. By binding to IL-1, Kineret can help reduce the symptoms of rheumatoid arthritis, along with the physical damage to the joints.
Kineret works to treat NOMID in the same manner (by inhibiting the inflammatory IL-1 protein). 

Using Kineret in Children

Kineret is not approved for treating rheumatoid arthritis in children (often known as juvenile rheumatoid arthritis). It is approved for treating NOMID in children, even babies. Talk to your healthcare provider about the benefits and risks of using the drug in children.

Off-Label Kineret Uses

On occasion, your healthcare provider may recommend Kineret for treating something other than rheumatoid arthritis. Currently, off-label Kineret uses include treatment of the following conditions:
  • Familial cold autoinflammatory syndrome (FCAS)
  • Muckle-Wells syndrome (MWS)
  • Uveitis (an eye condition).
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Kineret for Rheumatoid Arthritis

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