Krystexxa Side Effects

Some of the common side effects of Krystexxa include nausea, bruising, and shortness of breath. Usually, reactions to this medicine are minor and easily treated. However, it is important to tell your healthcare provider right away if you experience difficulty breathing, chest pain, or swelling of the mouth or throat while receiving the infusion, as it may be a sign of potentially dangerous complications.

An Introduction to Krystexxa Side Effects

Just like any medication, Krystexxa® (pegloticase) can cause side effects. However, not everyone who receives the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of Krystexxa's possible side effects. Your healthcare provider can discuss a more complete list with you.)

Common Side Effects of Krystexxa

Krystexxa has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people who received Krystexxa were documented and then compared to the side effects that occurred in a similar group of people who were given a placebo (a "sugar pill" that does not contain any active ingredients).
In these studies, some of the most common Krystexxa side effects included:
  • Gout flare-ups (a temporary worsening of gout) -- in up to 77 percent of people
  • Infusion reactions (such as hives, itching, shortness of breath, and chest pain) -- up to 26 percent
  • Nausea -- up to 12 percent
  • Bruising -- up to 11 percent
  • Common cold symptoms (such as a sore throat or runny nose) -- up to 7 percent
  • Constipation -- up to 6 percent
  • Chest pain -- up to 6 percent
  • Vomiting -- up to 5 percent.
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Krystexxa Medication Information

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