Krystexxa Uses

Krystexxa can help prevent gout attacks, but it is not very effective for treating a gout attack that has already started. This prescription medication is specifically designed for "refractory" cases of gout, which means Krystexxa is used in people who have not responded adequately to other gout medications. It is only approved for use in people age 18 and older.

What Is Krystexxa Used For?

Krystexxa® (pegloticase) is a prescription medication approved for the treatment of gout. It is reserved for "refractory" cases of gout (for use in people who have not responded adequately to other gout medications).
Gout is a very painful form of arthritis. It is caused in part by high uric acid levels (see Causes of Gout). Uric acid is a substance that results from the breakdown of purines, which are part of all human tissue and are found in many foods.
Normally, uric acid is dissolved in the blood and passed through the kidneys into the urine, where it is eliminated from the body. If the body increases its production of uric acid, or if the kidneys do not eliminate enough from the body, increased levels of uric acid build up in the blood.
Excess uric acid can form crystals in joints or other parts of the body. These crystals can lead to inflammation, causing painful gout symptoms. This increased level of uric acid in the blood can also lead to:
  • Deposits of uric acid (called tophi) that look like lumps under the skin around the joints and at the rim of the ear
  • Kidney stones from uric acid crystals in the kidneys.
Krystexxa is approved for treating gout. It works well for preventing gout attacks, although it is not very effective for treating a gout attack that is already occurring. In fact, it can temporarily worsen gout. For these reasons, Krystexxa is typically used along with other gout medications, especially at first.
There is no cure for gout, and medications may be more effective when combined with additional measures, such as a gout diet.
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Krystexxa Medication Information

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