Krystexxa Warnings and Precautions

Krystexxa can make certain heart problems worse and may cause potentially dangerous allergic reactions. If you have heart problems or uric acid levels higher than 6 mg/dL, your healthcare provider may advise against using Krystexxa. Precautions and warnings also extend to people with certain allergies, as well as women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Krystexxa® (pegloticase) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions for Krystexxa

Some warnings and precautions to be aware of prior to receiving this drug include the following:
  • Krystexxa can cause dangerous allergic reactions. Less serious (but still quite bothersome) "infusion reactions" may also occur. Signs of allergic reactions or infusion reactions might include:
    • An unexplained rash
    • Itching
    • Hives
    • Redness of the face
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing
    • Low blood pressure
    • Chest pain.
Let your healthcare know right away if you think you might be experiencing an allergic reaction or infusion reaction. Such reactions can occur during or after any dose of Krystexxa.
  • In order to prevent or reduce allergic reactions or infusion reactions, you should be given a corticosteroid and an antihistamine before each dose of Krystexxa.
  • The risk of allergic reactions or infusion reactions is higher in people with uric acid levels that are more than 6 mg/dL. Your healthcare provider may decide to monitor your uric acid levels (using a simple blood test) and might recommend against using this medication, especially if you have two consecutively high levels in a row.
  • Krystexxa works to prevent gout attacks; it does not help treat attacks that are already occurring. In fact, it can temporarily worsen gout, especially at first. For these reasons, Krystexxa is typically used along with other gout medications, especially for the first six months.
  • Krystexxa might possibly worsen congestive heart failure (CHF). If you have a history of heart problems, you may want to discuss this possibility with your healthcare provider.
  • Krystexxa is considered a pregnancy Category C medication. This means that it may not be safe to use this medication during pregnancy. Talk to your healthcare provider about the risks and benefits of using this drug during pregnancy (see Krystexxa and Pregnancy for more information).
  • It is not known if Krystexxa passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, make sure to talk with your healthcare provider about using Krystexxa (see Krystexxa and Breastfeeding).
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Krystexxa Medication Information

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