Krystexxa is a drug that is administered intravenously once every two weeks to treat gout. It works by decreasing the amount of uric acid in the blood. This medication is designed to prevent gout attacks; it is not very effective at treating a gout attack that has already started. Possible side effects may include nausea, bruising, and infusion reactions (such as hives and shortness of breath).
What Is Krystexxa?Krystexxa® (pegloticase) is a prescription medication approved for the treatment of gout. It is given intravenously (by IV) once every two weeks.
How Does Krystexxa Work?Krystexxa works by lowering uric acid levels. This helps to treat gout, as this condition occurs when the levels of uric acid become so high that uric acid crystals form inside the joint. The medication lowers uric acid levels by causing a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.
Krystexxa works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, Krystexxa is usually given along with other gout medications, at least temporarily.