Lodine XL Drug Interactions

Potential Lodine XL drug interactions may occur with drugs such as lithium, phenylbutazone, corticosteroids, and aspirin. When these or certain other medications are taken with Lodine XL, serious side effects can occur. Drug interactions with Lodine XL can put a person at an increased risk of bleeding, kidney damage, and stomach ulcers.

 

Lodine XL Drug Interactions: An Introduction

Lodine® XL (etodolac extended-release) has a number of medicines that it can potentially interact with. Some of these possible Lodine XL drug interactions include:
 

 

Several herbal and nutritional supplements can also interact with Lodine XL and may increase the risk of bleeding. Examples of these include, but are not limited to:
 
Warfarin (Coumadin, Jantoven)
If you are taking other blood thinners, such as warfarin, while taking Lodine XL, your body may metabolize them differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests used to measure how well your blood is clotting.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;