Arthritis Home > Allopurinol Dosage

Before determining your allopurinol dosage, your healthcare provider will consider several factors, such as the condition being treated and the severity of the condition. It is generally recommended to take other gout medications along with allopurinol when first starting allopurinol, as it takes a few weeks or months for it to start working. To prevent kidney stones, it's important to take your dose of allopurinol with plenty of fluids.

An Introduction to Allopurinol Dosages

The dosage of allopurinol (Zyloprim®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The medical condition being treated
  • The severity of your condition
  • How you respond to the medication
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Dosage for Gout

To help avoid a flare-up of gout attacks (which can occur when starting allopurinol), it is recommended to start at a low dosage for treating gout: allopurinol 100 mg once daily. After that, your healthcare provider may increase your dose by 100 mg per day each week, until the maximum dose is reached (800 mg daily) or until your uric acid levels are under control (are 6 mg/dL or less). People with kidney disease should take a lower dose, depending on the severity of their kidney problems.
Unlike some gout medications, allopurinol is taken all the time, because this medication works to prevent gout attacks (not to treat them). It is usually recommended to take other gout medications along with allopurinol (when first starting allopurinol), as it takes a few weeks or months for it to start working. Also, allopurinol can initially cause gout attacks.
Doses of 300 mg or less can be taken as a single daily dose, but higher doses should be split up into a few (usually two or three) smaller doses per day.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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