Arthritis Home > Arthrotec

As a combination medication, Arthrotec contains two different drugs that work to treat the symptoms of certain types of arthritis while also preventing ulcers. This prescription medicine comes in the form of a tablet and is taken by mouth two to four times daily. Most people tolerate it well, but side effects are possible and may include diarrhea, heartburn, and nausea.

What Is Arthrotec?

Arthrotec® (diclofenac/misoprostol) is a combination prescription medication approved to treat the symptoms of certain types of arthritis in people who are at risk for peptic ulcers from the use of nonsteroidal anti-inflammatory drugs (NSAIDs). It contains diclofenac sodium (Voltaren®, Voltaren®-XR), an NSAID that is used to relieve the symptoms of arthritis, and misoprostol (Cytotec®), a prostaglandin that helps reduce the risk of ulcers.
 
(Click Arthrotec Uses for more information on this topic, including possible off-label uses.)
 

Who Makes This Medication?

Arthrotec is manufactured by Pfizer, Inc., and distributed by G.D. Searle, LLC., a division of Pfizer, Inc.
 

How Does Arthrotec Work?

Arthrotec combines two different medications that work in different ways. Diclofenac sodium, the pain-relieving component, works by blocking the production of prostaglandins, which are hormone-like substances in the body that cause inflammation and pain. By blocking the production of prostaglandins, diclofenac can reduce pain, inflammation, and joint swelling associated with arthritis.
 
Misoprostol, the other component of Arthrotec, is a type of prostaglandin. It works by decreasing stomach acid secretion and protecting the lining of the stomach from stomach acid and other harmful substances.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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