As a combination medication, Arthrotec contains two different drugs that work to treat the symptoms of certain types of arthritis while also preventing ulcers. This prescription medicine comes in the form of a tablet and is taken by mouth two to four times daily. Most people tolerate it well, but side effects are possible and may include diarrhea, heartburn, and nausea.
Arthrotec is manufactured by Pfizer, Inc., and distributed by G.D. Searle, LLC., a division of Pfizer, Inc.
How Does Arthrotec Work?
Arthrotec combines two different medications that work in different ways. Diclofenac sodium, the pain-relieving component, works by blocking the production of prostaglandins, which are hormone-like substances in the body that cause inflammation and pain. By blocking the production of prostaglandins, diclofenac can reduce pain, inflammation, and joint swelling associated with arthritis.
Misoprostol, the other component of Arthrotec, is a type of prostaglandin. It works by decreasing stomach acid secretion and protecting the lining of the stomach from stomach acid and other harmful substances.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Arthrotec [package insert]. New York, NY: G.D. Searle, LLC.;2010 December.
Lexi-Interact [computer program]. Lexi-Comp, Inc.; February 9, 2012.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed November 16, 2012.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed February 10, 2012.
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