Arthritis Home > Drug Interactions With Etodolac

When certain medications are taken together, there is always the risk of developing negative drug interactions. When taken with etodolac, medicines such as lithium, methotrexate, and digoxin can cause an adverse effect that may lead to serious complications. These etodolac drug interactions can cause increased levels of the drugs in your system, stomach ulcers, bleeding, or kidney damage, among other things.

Interactions With Etodolac: An Introduction

Etodolac (Lodine®) has a number of medicines that it can potentially interact with. Some of these drug interactions include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
Several herbal and nutritional supplements can also interact with etodolac and may potentially increase the risk of bleeding. Examples of these include, but are not limited to:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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