Arthritis Home > Other Ways to Prevent Gout
Another type of drug (known as uricosuric medication) is used to increase the amount of uric acid removed in urine. Two uricosuric drugs commonly used as preventive gout treatments are:
- Probenecid (Benemid®)
- Sulfinpyrazone (Anturane®).
Pegloticase (Krystexxa®) is a prescription medication approved for preventing gout attacks. It is reserved for "refractory" cases of gout (for use in people who have not responded adequately to other gout medications). It is given by IV once every two weeks.
Pegloticase lowers uric acid levels by encouraging a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.
Pegloticase works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, pegloticase is usually taken along with other gout medications, at least temporarily.