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Gout Prevention by Increasing Uric Acid Excretion

Another type of drug (known as uricosuric medication) is used to increase the amount of uric acid removed in urine. Two uricosuric drugs commonly used as preventive gout treatments are:

 
  • Probenecid (Benemid®)
  • Sulfinpyrazone (Anturane®).
     
Both of these medicines are approved for to treat gout. In addition to lowering blood uric acid levels, these drugs help dissolve deposits of uric acid crystals around joints and in other tissue.
 
Uricosurics can cause nausea, stomach upset, headache, and a potentially serious skin rash.
 
Gout Prevention by Breaking Down Uric Acid

Pegloticase (Krystexxa®) is a prescription medication approved for preventing gout attacks. It is reserved for "refractory" cases of gout (for use in people who have not responded adequately to other gout medications). It is given by IV once every two weeks.

 

Pegloticase lowers uric acid levels by encouraging a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.

 

Pegloticase works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, pegloticase is usually taken along with other gout medications, at least temporarily.

Written by/reviewed by:
Last reviewed by: Arthur Schoenstadt, MD
Last updated/reviewed:
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