Arthritis Home > Kineret

Kineret is a prescription drug that is used for treating rheumatoid arthritis in people who have not responded well to other medications. It can also treat neonatal-onset multisystem inflammatory disease. The medication is given as a daily injection, either by you or a healthcare provider. Side effects may include nausea, headache, and diarrhea.

What Is Kineret?

Kineret® (anakinra) is a prescription medication used to treat rheumatoid arthritis. Specifically, it is approved to treat moderate to severe rheumatoid arthritis in people who have not adequately responded to other rheumatoid arthritis medications. It is given as a daily injection just under the skin.
Kineret is also approved to treat a very rare disorder known as neonatal-onset multisystem inflammatory disease (NOMID).
(Click Kineret Uses for more information, including possible off-label uses.)

Who Makes Kineret?

Kineret is made by Swedish Orphan Biovitrum.

How Does Kineret Work?

People with rheumatoid arthritis often have high levels of a certain protein called interleukin-1 (IL-1) in their joints. IL-1 causes inflammation, cartilage damage, and bone erosion. Kineret is a synthetic form of a different naturally occurring protein in the body that inhibits the effects of IL-1. By binding to IL-1, Kineret can help reduce the symptoms of rheumatoid arthritis, along with the physical damage to the joints.
Kineret works to treat NOMID in the same manner (by inhibiting the inflammatory IL-1 protein). 
Because Kineret targets a specific part of the immune system (IL-1), it is called a "biological response modifier" because it changes (modifies) the body's immune response. It is also known as a "biologic" medication, because it is a protein.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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