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Krystexxa is a drug that is administered intravenously once every two weeks to treat gout. It works by decreasing the amount of uric acid in the blood. This medication is designed to prevent gout attacks; it is not very effective at treating a gout attack that has already started. Possible side effects may include nausea, bruising, and infusion reactions (such as hives and shortness of breath).

What Is Krystexxa?

Krystexxa® (pegloticase) is a prescription medication approved for the treatment of gout. It is given intravenously (by IV) once every two weeks.
(Click Krystexxa Uses for more information, including possible off-label uses.)

Who Makes This Medication?

Krystexxa is made by Savient Pharmaceuticals, Inc.

How Does Krystexxa Work?

Krystexxa works by lowering uric acid levels. This helps to treat gout, as this condition occurs when the levels of uric acid become so high that uric acid crystals form inside the joint. The medication lowers uric acid levels by causing a chemical reaction that converts uric acid into allantoin, a harmless substance that is excreted from the body in the urine.
Krystexxa works well for preventing gout attacks, but it is not very effective for treating a gout attack that is already occurring. In fact, sometimes it temporarily seems to make gout worse at first. For these reasons, Krystexxa is usually given along with other gout medications, at least temporarily.

Effects of Krystexxa

Studies have shown that Krystexxa lowers uric acid levels in the blood more effectively than a placebo (in this case, an IV fluid that does not contain any active ingredients). For instance, one study looked at the percentage of people who were able to lower their uric acid levels to 6 mg/dL or lower. In this study, 47 percent of people who received Krystexxa every two weeks achieved this goal, compared to 0 percent of people who were given the placebo.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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