Arthritis Home > Products That Interfere With Lodine XL

Diuretics
Combining Lodine XL with a diuretic can increase the risk of kidney problems, especially in people who already have kidney problems, and can decrease the effectiveness of the diuretic.
 
Lithium
Taking Lodine XL and lithium together may increase the levels of lithium in your body by reducing the kidneys' ability to remove lithium. Your healthcare provider may need to adjust your dose of these drugs and monitor the level of lithium in your blood.
 
"Blood Thinners" and Other Similar Drugs
Combining Lodine XL with anticoagulants ("blood thinners"), antiplatelet drugs, or other medications that increase the risk of bleeding may lead to serious bleeding problems, including dangerous internal bleeding. Do not combine Lodine XL with such medications without your healthcare provider's approval and supervision.
 
Methotrexate
Lodine XL may increase the risk of methotrexate toxicity. Do not combine these medications without your healthcare provider's supervision and approval.
 
Probenecid
Probenecid may increase the level of Lodine XL in the blood, increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
SSRIs or SNRIs
Combining a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) with Lodine XL may increase the risk of bleeding. Check with your healthcare provider before taking Lodine XL with an SSRI or SNRI.
 
Herbal and/or Nutritional Supplements
Several herbal and nutritional supplements can also interact with Lodine XL and may increase the risk of bleeding. If you are taking any natural or herbal supplements, make sure to discuss it with your healthcare provider before starting Lodine XL therapy.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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