Arthritis Home > Lodine XL

Lodine XL is used to treat pain, joint swelling, and inflammation caused by various types of arthritis. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs. The medication comes in the form of a tablet and is available in three different strengths. Potential side effects can include nausea, heartburn or indigestion, and vomiting.

What Is Lodine XL?

Lodine® XL (etodolac extended-release) is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to reduce pain, inflammation, swelling, and/or stiffness caused by juvenile rheumatoid arthritis, osteoarthritis, or rheumatoid arthritis. The medication is not a cure for these types of arthritis, however, nor does it slow down the progression of the disease.
(Click Lodine XL Uses for more information, along with possible off-label uses.)

Who Makes the Drug?

Lodine XL was manufactured by Wyeth Pharmaceuticals but is no longer being made. Generic versions are still available.

How Does Lodine XL Work?

Lodine XL and other NSAIDs work by inhibiting the action of certain hormones that cause inflammation and pain in the body. These hormones are called prostaglandins.
By blocking the effects of prostaglandins, Lodine XL is useful at reducing pain, inflammation, and joint swelling associated with different forms of arthritis.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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