Arthritis Home > Naproxen Sodium Drug Interactions

When certain medicines are taken with naproxen sodium, drug interactions may develop. Drugs that can potentially cause an interaction include methotrexate, diuretics, beta blockers, and ACE inhibitors. Your body may metabolize these drugs differently than intended, and side effects may occur, such as stomach ulcers or increased risk of bleeding. Some interactions may also increase the level of medicine in your blood.

Naproxen Sodium Interactions: An Overview

Naproxen sodium (brand names include Aleve®, Anaprox®, and Naprelan®) can potentially interact with several different medicines. Some of the medicines that can cause drug interactions with naproxen sodium include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with naproxen sodium and may increase the risk of bleeding. Examples of these include but are not limited to:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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