Arthritis Home > Drug Interactions With Piroxicam

Lithium, warfarin, aspirin, and cyclosporine are some of the drugs that can interact with piroxicam. Drug interactions can increase the risk of stomach ulcers, kidney damage, and bleeding, as well as change the way your body metabolizes the medications. Before taking piroxicam, talk with your healthcare provider about any interactions that may apply to you.

Piroxicam Interactions: An Overview

Piroxicam (Feldene®) can potentially interact with a number of medicines. Some of the medications that may cause drug interactions with piroxicam include:
 
 
  • Angiotensin II receptor blockers (ARBs), such as:

 

 
 
 
  • Corticosteroids, including (but not limited to):
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
 
 
 
Several herbal and nutritional supplements can also interact with piroxicam and may increase the risk of bleeding. Examples of these include but are not limited to:
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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